abstract：:Testosterone can be converted into androstenedione (4-dione) by 17β-hydroxysteroid dehydrogenase (HSD) activity likely performed by 17β-HSD type 2. Our objective was to evaluate the rate of testosterone conversion to 4-dione as well as expression and localization of 17β-HSD type 2 in omental (OM) vs. subcutaneous (SC)...

journal_title：Molecular and cellular endocrinology

authors： Fouad Mansour M,Pelletier M,Boulet MM,Mayrand D,Brochu G,Lebel S,Poirier D,Fradette J,Cianflone K,Luu-The V,Tchernof A

更新日期：2015-10-15 00:00:00

abstract：:Yin Yang 1 (YY1) is an ubiquitously distributed transcription factor that belongs to the GLI-Kruppel class of zinc finger proteins. The mechanism by which YY1 regulates adipocyte differentiation remains unclear. In this study, we investigated the functional role of YY1 during adipocyte differentiation. During the earl...

journal_title：Molecular and cellular endocrinology

authors： Han Y,Choi YH,Lee SH,Jin YH,Cheong H,Lee KY

更新日期：2015-09-15 00:00:00

abstract：:In previous studies, we found that endometriotic stromal cells lose the ability to regulate cell survival signaling in endometriotic epithelial cells. Here, we invested the effect of Metformin on the stromal-epithelial cells crosstalk in endometriosis and explored the pathway that might be involved. We found that ecto...

journal_title：Molecular and cellular endocrinology

authors： Zhang H,Xue J,Li M,Zhao X,Wei D,Li C

更新日期：2015-09-15 00:00:00

abstract：:Alternative mRNA splicing diversifies the products encoded by the NCoR and SMRT corepressor loci. There is a programmed alteration in NCoR mRNA splicing during adipocyte differentiation from an NCoRω isoform, which contains three nuclear receptor interaction domains, to an NCoRδ isoform that contains two nuclear recep...

journal_title：Molecular and cellular endocrinology

authors： Snyder CA,Goodson ML,Schroeder AC,Privalsky ML

更新日期：2015-09-15 00:00:00

abstract：:Glomerulosa cells secrete aldosterone in response to agonists coupled to Ca(2+) increases such as angiotensin II and corticotrophin, coupled to a cAMP dependent pathway. A recently recognized interaction between Ca(2+) and cAMP is the Ca(2+)-induced cAMP formation in the mitochondrial matrix. Here we describe that sol...

journal_title：Molecular and cellular endocrinology

authors： Katona D,Rajki A,Di Benedetto G,Pozzan T,Spät A

更新日期：2015-09-05 00:00:00

abstract：:Bisphenol A (BPA) and para-Nonylphenol (p-NP) are chemicals of industrial origin which may influence human reproductive health. The effects of these substances in the prenatal life is an important topic that is receiving greater attention in the developed countries. In this study, human trophoblast cells HTR-8/SVneo w...

journal_title：Molecular and cellular endocrinology

authors： Spagnoletti A,Paulesu L,Mannelli C,Ermini L,Romagnoli R,Cintorino M,Ietta F

更新日期：2015-09-05 00:00:00

abstract：:Type-1 diabetes (T1D) is a heterogeneous autoimmune disease, and there are pathogenetic differences between young- and adult-onset T1D patients. We hypothesized that the expressions of genes involved in costimulatory immune system pathways in peripheral blood are differently regulated in young- and adult-onset T1D. St...

journal_title：Molecular and cellular endocrinology

authors： Pruul K,Kisand K,Alnek K,Metsküla K,Reimand K,Heilman K,Peet A,Varik K,Peetsalu M,Einberg Ü,Tillmann V,Uibo R

更新日期：2015-09-05 00:00:00

abstract：:Calcium homeostasis refers to the regulation of calcium ion concentration in the body. This concentration is tightly controlled by a stabilizing system consisting of calcium channels and calcium buffering proteins. Calcium homeostasis is crucial for cell survival. Various forms of cell death (e.g., necrosis and apopto...

journal_title：Molecular and cellular endocrinology

authors： Ahn C,An BS,Jeung EB

更新日期：2015-09-05 00:00:00

abstract：:While vitamin D supplementation is common, the anabolic mechanisms that improve bone status are poorly understood. Under standard mineralising conditions including media ionised calcium of 1.1 mM, 1,25-dihydroxyvitamin D3 (1,25D) enhanced differentiation and mineral deposition by the mature osteoblast/pre-osteocyte ce...

journal_title：Molecular and cellular endocrinology

authors： Yang D,Turner AG,Wijenayaka AR,Anderson PH,Morris HA,Atkins GJ

更新日期：2015-09-05 00:00:00

abstract：:Semicarbazide-sensitive amine oxidase (SSAO), an enzyme highly expressed on adipocyte plasma membranes, converts primary amines into aldehydes, ammonium and hydrogen peroxide, and is likely involved in endothelial damage during the course of diabetes and obesity. We investigated whether in vitro, adipocyte SSAO was mo...

journal_title：Molecular and cellular endocrinology

authors： Repessé X,Moldes M,Muscat A,Vatier C,Chetrite G,Gille T,Planes C,Filip A,Mercier N,Duranteau J,Fève B

更新日期：2015-08-15 00:00:00

abstract：:Thrombin and COX-2 regulating cardiac hypertrophy are via various signaling cascades. Several transcriptional factors including CREB involve in COX-2 expression. However, the interplay among thrombin, CREB, and COX-2 in primary human neonatal ventricular cardiomyocytes remains unclear. In this study, thrombin-induced ...

journal_title：Molecular and cellular endocrinology

authors： Chien PT,Lin CC,Hsiao LD,Yang CM

更新日期：2015-07-05 00:00:00

abstract：:The congenital adrenal hyperplasias (CAH) are a group of genetic defects in cortisol biosynthesis, most commonly steroid 21-hydroxylase deficiency (21OHD). With the advent of cortisone therapy in the 1960s and newborn screening in the 1990s, most children with 21OHD now reach adulthood. The needs and concerns of adult...

journal_title：Molecular and cellular endocrinology

authors： Auchus RJ

更新日期：2015-06-15 00:00:00

abstract：:The activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterized by an ultradian (pulsatile) pattern of hormone secretion. Pulsatility of glucocorticoids has been found critical for optimal transcriptional, neuroendocrine and behavioral responses. This review will focus on the mechanisms underlying the o...

journal_title：Molecular and cellular endocrinology

authors： Spiga F,Lightman SL

更新日期：2015-06-15 00:00:00

abstract：:The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial i...

journal_title：Molecular and cellular endocrinology

authors： Castillo AF,Orlando U,Helfenberger KE,Poderoso C,Podesta EJ

更新日期：2015-06-15 00:00:00

abstract：:A critical regulatory component of the hypothalamus/pituitary/adrenal axis (HPA) in mammals, reptiles and birds, and in the hypothalamus/pituitary/interrenal (HPI) axis of amphibians and teleosts (modern bony fishes) is the strict ligand selectivity of the melanocortin-2 receptor (MC2R). Tetrapod and teleost MC2R orth...

journal_title：Molecular and cellular endocrinology

authors： Dores RM,Garcia Y

更新日期：2015-06-15 00:00:00

abstract：:Sepsis and septic shock in response to bacterial or viral infections remain the major health problem worldwide. Despite decades of intensive research and improvements in medical care, severe sepsis is associated with high mortality. Rapid activation of the adrenal gland glucocorticoid and catecholamine production is a...

journal_title：Molecular and cellular endocrinology

authors： Kanczkowski W,Sue M,Zacharowski K,Reincke M,Bornstein SR

更新日期：2015-06-15 00:00:00

abstract：:Di-(2-ethylhexyl)-phthalate (DEHP) accumulates in the environment, and its exposure is possibly associated with endocrine-related disease in women of reproductive age. The effects of DEHP on human endometrial cells are unknown. We treated human endometrial stromal cells with 10, 100, and 1000 pmol of DEHP and measured...

journal_title：Molecular and cellular endocrinology

authors： Cho YJ,Park SB,Han M

更新日期：2015-05-15 00:00:00

abstract：:Osterix, a zinc-finger transcription factor, is required for osteoblast differentiation and new bone formation during embryonic development. The c-Src of tyrosine kinase is involved in a variety of cellular signaling pathways, leading to the induction of DNA synthesis, cell proliferation, and cytoskeletal reorganizati...

journal_title：Molecular and cellular endocrinology

authors： Choi YH,Han Y,Lee SH,Cheong H,Chun KH,Yeo CY,Lee KY

更新日期：2015-05-15 00:00:00

abstract：:The FOXO1 transcription factor is important for multiple aspects of reproductive function. We previously reported that FOXO1 functions as a repressor of gonadotropin hormone synthesis, but how FOXO1 is regulated in pituitary gonadotropes is unknown. The growth factors, insulin and insulin-like growth factor I (IGF1), ...

journal_title：Molecular and cellular endocrinology

authors： Skarra DV,Thackray VG

更新日期：2015-04-15 00:00:00

abstract：:The NIH has recently highlighted the importance of sexual dimorphisms and has mandated inclusion of both sexes in clinical trials and basic research. In this review we highlight new and novel ways sex hormones influence body adiposity and the metabolic syndrome. Understanding how and why metabolic processes differ by ...

journal_title：Molecular and cellular endocrinology

authors： Palmer BF,Clegg DJ

更新日期：2015-02-15 00:00:00

abstract：:Oleic (OA) and linoleic (LA) fatty acids may be important regulators of Slc2a4 gene (GLUT4 protein) in skeletal muscle, thus participating in insulin resistance. We investigated the effect of OA and LA on the Slc2a4/GLUT4 expression in L6 muscle cells; as well as potential transcriptional regulators. OA and LA (50-400...

journal_title：Molecular and cellular endocrinology

authors： Poletto AC,Furuya DT,David-Silva A,Ebersbach-Silva P,Santos CL,Corrêa-Giannella ML,Passarelli M,Machado UF

更新日期：2015-02-05 00:00:00

abstract：:Compromise of gastric inhibitory polypeptide (GIP) receptor signalling represents a possible therapeutic strategy for the treatment of obesity-related diabetes. This study has characterised and evaluated the C-terminally fatty acid derivatised GIP analogues, GIP(3-30)Cex-K(40)[Pal] and Pro(3)GIP(3-30)Cex-K(40)[Pal], a...

journal_title：Molecular and cellular endocrinology

authors： Pathak V,Gault VA,Flatt PR,Irwin N

更新日期：2015-02-05 00:00:00

abstract：:Estrogen receptors (ers) not only are activated by hormones but also interact with many human-derived environmental contaminants. Here, we present evidence for four expressed er genes in Atlantic salmon cDNA - two more ers (erα2 and erβ2) than previously published. To determine if er gene expression differs between tw...

journal_title：Molecular and cellular endocrinology

authors： Nikoleris L,Hansson MC

更新日期：2015-01-15 00:00:00

abstract：:Primary aldosteronism (PA) encompasses a broad, heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most common form of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential h...

journal_title：Molecular and cellular endocrinology

authors： Monticone S,Else T,Mulatero P,Williams TA,Rainey WE

更新日期：2015-01-05 00:00:00

abstract：:The cannabinoid receptor subtype 1 gene CNR1 is not only associated with phenotypes such as cognitive performance, addiction and anxiety, but is also known to be crucially involved in responses to acute and chronic psychological and cellular stress conditions. Functional analysis of the 5' untranslated regions of the ...

journal_title：Molecular and cellular endocrinology

authors： Eggert M,Pfob M,Jurinovic V,Schelling G,Steinlein OK

更新日期：2015-01-05 00:00:00

abstract：:Foxp3+ regulatory T cells (Tregs) in lymphocytes facilitate the thyroid tumor growth and invasion. Very limited information is available on Foxp3 expression in thyroid cancer cells and its function is totally unknown. This study demonstrated that Foxp3 expression was increased in thyroid cancer cells. Inhibition of Fo...

journal_title：Molecular and cellular endocrinology

authors： Chu R,Liu SY,Vlantis AC,van Hasselt CA,Ng EK,Fan MD,Ng SK,Chan AB,Du J,Wei W,Liu X,Liu Z,Chen GG

更新日期：2015-01-05 00:00:00

abstract：:The aim of this study was to elucidate whether metformin can regulate the expression of vascular endothelial growth factor (VEGF) in rat-derived uterine leiomyoma cells (ELT-3 cells). In vitro studies were conducted using ELT-3 cells. Under normoxic conditions, metformin suppressed VEGF protein levels in the supernata...

journal_title：Molecular and cellular endocrinology

authors： Tadakawa M,Takeda T,Li B,Tsuiji K,Yaegashi N

更新日期：2015-01-05 00:00:00

abstract：:Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from bacteria by forming a barrier of fibrous layers in avian eggs. Although VMO1 is expressed in the o...

journal_title：Molecular and cellular endocrinology

authors： Lim W,Song G

更新日期：2015-01-05 00:00:00

abstract：:Expression of insulin-like growth factor 1 (IGF-1) mRNAs splice forms was recently shown to be stimulated by myofibrillar proteins released from the damaged muscle. In this study, we report that individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF...

journal_title：Molecular and cellular endocrinology

authors： Kravchenko IV,Furalyov VA,Chatziefthimiou S,Wilmanns M,Popov VO

更新日期：2015-01-05 00:00:00

abstract：:Di-n-Butyl (DBP) and Di-(2-EthylHexyl) (DEHP) phthalates can leach from daily-use products resulting in environmental exposure. In male rodents, phthalate exposure results in reproductive effects. To evaluate effects on the immature primate testis, testis fragments from 6-month-old rhesus macaques were grafted subcuta...

journal_title：Molecular and cellular endocrinology

authors： Rodriguez-Sosa JR,Bondareva A,Tang L,Avelar GF,Coyle KM,Modelski M,Alpaugh W,Conley A,Wynne-Edwards K,França LR,Meyers S,Dobrinski I

更新日期：2014-12-01 00:00:00

abstract：:Genomewide association studies (GWAS) have indicated that SNPs on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity. GWAS, however, are by nature gene agnostic, and SNPs reaching the appropriate statistical threshold for a given phenotype can appear a...

journal_title：Molecular and cellular endocrinology

authors： Yeo GS

更新日期：2014-11-01 00:00:00

abstract：:The transcription factor Pax8 is already known to be essential at very early stages of mouse thyroid gland development, before the onset of thyroid hormone production. In this paper we show, using a conditional inactivation strategy, that the removal of the Pax8 protein late in gland development results in severe hypo...

journal_title：Molecular and cellular endocrinology

authors： Marotta P,Amendola E,Scarfò M,De Luca P,Zoppoli P,Amoresano A,De Felice M,Di Lauro R

更新日期：2014-10-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease in the vessel. As a representative inflammatory cytokine, C-reactive protein (CRP) participates in atherogenesis. Although hyperaldosteronism is known to evoke inflammatory response in several tissues and cell types, there is no direct evidence to demonstrate the proin...

journal_title：Molecular and cellular endocrinology

authors： Zhang X,Liu J,Pang X,Zhao J,Wang S,Wu D

更新日期：2014-09-01 00:00:00

abstract：:Pioglitazone belongs to the class of drugs called thiazolidinediones (TZDs), which are widely used as insulin sensitizers in the treatment of diabetes. A major side effect of TZDs is fluid retention. The steroid hormone aldosterone also promotes sodium and fluid retention; however, the effect of pioglitazone on aldost...

journal_title：Molecular and cellular endocrinology

authors： Pan ZQ,Xie D,Choudhary V,Seremwe M,Tsai YY,Olala L,Chen X,Bollag WB

更新日期：2014-08-25 00:00:00

abstract：BACKGROUND:Inflammation is believed to link obesity to insulin resistance, as in the setting of metabolic syndrome (MetS). Osteoprotegerin (OPG) is a soluble protein that seems to exert proatherogenic and prodiabetogenic effects. This study aims at determining OPG levels in MetS and whether OPG might contribute to MetS...

journal_title：Molecular and cellular endocrinology

authors： Bernardi S,Fabris B,Thomas M,Toffoli B,Tikellis C,Candido R,Catena C,Mulatero P,Barbone F,Radillo O,Zauli G,Secchiero P

更新日期：2014-08-25 00:00:00

abstract：:Visceral obesity is an independent risk factor for metabolic syndrome, and abnormal fat accumulation is linked to increases in the number and size of adipocytes. MiR-146b was a miRNA highly expressed in mature adipocytes while very lowly expressed in human mesenchymal stem cells (hMSCs) and human visceral preadipocyte...

journal_title：Molecular and cellular endocrinology

authors： Chen L,Dai YM,Ji CB,Yang L,Shi CM,Xu GF,Pang LX,Huang FY,Zhang CM,Guo XR

更新日期：2014-08-05 00:00:00

abstract：:Our objective was to investigate the mechanisms by which the endogenous CRHR2 in white adipose tissue (WAT) regulates metabolic activities associated with lipogenesis and lipolysis under continuous exposure to hypoxia. We found that hypobaric hypoxia at a simulated altitude of 5000 m significantly reduced the body wei...

journal_title：Molecular and cellular endocrinology

authors： Xiong Y,Qu Z,Chen N,Gong H,Song M,Chen X,Du J,Xu C

更新日期：2014-07-05 00:00:00

abstract：:cAMP signalling plays a key role in the normal physiology of the pituitary gland, regulating cellular growth and proliferation, hormone production and release. Deregulation of the cAMP signalling pathway has been reported to be a common occurrence in pituitary tumorigenesis. Several mechanisms have been implicated inc...

journal_title：Molecular and cellular endocrinology

authors： Formosa R,Vassallo J

更新日期：2014-07-05 00:00:00

abstract：:Estrogens are the primary female sex hormones and play important roles in both reproductive and non-reproductive systems. Estrogens can be synthesized in non-reproductive tissues such as liver, heart, muscle, bone and the brain. During the past decade, increasing evidence suggests that brain estrogen can not only be s...

journal_title：Molecular and cellular endocrinology

authors： Li R,Cui J,Shen Y

更新日期：2014-05-25 00:00:00

abstract：:The objective of the study was to identify microRNAs (miRs) characteristic for follicular thyroid carcinoma (FTC) and to define their role in tumorigenesis. A miR-microarray study was conducted to identify miRs differentially expressed between FTCs and their surrounding tissues. Selection was further reinforced by a l...

journal_title：Molecular and cellular endocrinology

authors： Wojtas B,Ferraz C,Stokowy T,Hauptmann S,Lange D,Dralle H,Musholt T,Jarzab B,Paschke R,Eszlinger M

更新日期：2014-05-05 00:00:00